Cardiovascular Medicine

Edition 2024/03

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CVM

New Responsibilities for the HEART-Team

Editorial
Luca Koechlin
Published on 29.05.2024
Luca Koechlin
In this issue of Cardiovascular Medicine, Bashir Alaour and Thomas Pilgrim take on the demanding task of summarizing the challenges involved in the management of patients with aortic stenosis over the course of their lives. In their engaging review, the authors emphasize the importance of a patient-tailored approach in the lifetime management of aortic stenosis. As a result, it is essential that not only interventional cardiologists and surgeons but also resident cardiologists and general practitioners are involved in finding the best management for each individual patient, from the diagnosis to intervention and any potential re-intervention.
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Bashir Alaour, et. al.
Published on 29.05.2024
Bashir Alaour
+1

Despite an extensive body of literature, there are still many gaps in the evidence surrounding the lifetime management of aortic stenosis (AS) and upstream interventions to prevent or slow down the progression of the disease are yet to be developed.

Isabella Sudano
Published on 29.05.2024
Isabella Sudano

Bempedoic acid is a fairly small molecule acting as a prodrug which is converted into the active compound bempedoyl-CoA in the liver. This active metabolite of bempedoic acid inhibits the enzyme ATP citrate lyase leading to low-density lipoprotein (LDL) reduction.

The CLEAR (Cholesterol Lowering via Bempedoic Acid, an ACL-Inhibiting Regimen) Harmony trial showed that bempedoic acid reduced LDL cholesterol (LDL-C) by 12.6–16.5% and the CLEAR Tranquility and Serenity showed a reduction of LDL-C in statin-intolerant patients by a mean of 21% in monotherapy and 38% in combination with ezetimibe.

Myriam Kaddour, et. al.
Published on 29.05.2024
Myriam Kaddour
+1

His bundle pacing is the most physiological form of pacing as it replicates the patient’s natural ventricular activation. Its adoption has significantly grown over the last years. However, the technique has several limitations, including suboptimal thresholds. Left bundle branch area pacing has been introduced more recently and has gained much interest as it also delivers physiological pacing but with more favorable electrical parameters. However, there are also several unresolved issues with this technique. This article compares these strategies and highlights their advantages and disadvantages to provide guidance on which technique to select for a specific patient.

Abhishek Potnis, et. al.
Published on 29.05.2024
Abhishek Potnis
+2

Takotsubo cardiomyopathy is a type of stress cardiomyopathy that is usually seen in postmenopausal patients and can be triggered by emotional stress, hypoglycemia, hypothyroidism, and surgery. A patient post cardiac surgery can present with multiple complications causing hemodynamic compromise. Hence, takotsubo cardiomyopathy remains a diagnostic dilemma. Here, we present an interesting electrocardiogram (ECG) of the same condition in a patient after mitral valve replacement with normal patent coronaries but presenting with anterolateral massive infarction with shark fin pattern in the ECG.

Hari Vivekanantham, et. al.
Published on 29.05.2024
Hari Vivekanantham
+1

We present the case of a young male presenting with a wide complex tachycardia. The diagnostic approach based on the electrocardiogram findings is discussed. The final diagnosis could be made following an adenosine challenge at baseline, underlying the use of this drug for diagnostic purposes even in the absence of ongoing tachycardia.